|
KMID : 0923620110110050288
|
|
Immune Network
2011 Volume.11 No. 5 p.288 ~ p.298
|
|
|
Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation
|
|
Moon Sun-Hee
Shin Seul-Mee
Kim Seul-Ah
Oh Hee-Eun
Han Shin-Ha
Kim Kyung-Jae
Lee Seung-Jeong
|
|
|
Abstract
|
|
|
Background: Salvia miltiorrhiza (SM) has been used to treat inflammatory diseases including edema and arthritis; however, the anti-inflammatory mechanism of SM action remains unresolved.
Methods: The effects of an ethanol extract of SM (ESM) on pro-inflammatory cytokines such as TNF-?, IL-1?, IL-6, and NO, on anti-inflammatory cytokines including IL-4, IL-10, TGF-?, and IL-1Ra have been studied in an attempt to elucidate the anti-inflammatory mechanism in murine macrophages.
Results: ESM inhibited the production of pro-inflammatory cytokines via down-regulation of gene and protein expression whereas it increased the anti-inflammatory cytokines. Furthermore, ESM inhibited the expression of the chemokines, RANTES and CX3CL1, as well as of inflammatory mediators such as TLR-4 and 11?- HSD1.
Conclusion: These results indicated that the regulatory effects of ESM may be mediated though the suppression of pro-inflammatory cytokines as well as the induction of anti-inflammatory cytokines. Consequently, we speculate that ESM has therapeutic potential for inflammation-associated disorders.
|
|
|
KEYWORD
|
|
|
Salvia miltiorrhiza, Pro-inflammatory cytokines, Chemokine, Th2 cytokine
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
   
|
|